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1

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

Chang, Jianhui, Wang, Yingying, Shao, Lijian, Laberge, Remi-Martin, Demaria, Marco, Campisi, Judith, Janakiraman, Krishnamurthy, Sharpless, Norman E, Ding, Sheng, Feng, Wei, Luo, Yi, Wang, Xiaoyan, Ay

Journal:

Nature Medicine

Year:

2015

Language:

english

File:

PDF, 1.32 MB

english, 2015

2

COVID-19 and cancer

Sharpless, Norman E.

Journal:

Year:

2020

File:

PDF, 97 KB

2020

3

Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a

Janzen, Viktor, Forkert, Randolf, Fleming, Heather E., Saito, Yoriko, Waring, Michael T., Dombkowski, David M., Cheng, Tao, DePinho, Ronald A., Sharpless, Norman E., Scadden, David T.

Journal:

Year:

2006

Language:

english

File:

PDF, 1013 KB

english, 2006

4

The mighty mouse: genetically engineered mouse models in cancer drug development

Sharpless, Norman E., DePinho, Ronald A.

Journal:

Nature Reviews Drug Discovery

Year:

2006

Language:

english

File:

PDF, 597 KB

english, 2006

5

How stem cells age and why this makes us grow old

Sharpless, Norman E., DePinho, Ronald A.

Journal:

Nature Reviews Molecular Cell Biology

Year:

2007

Language:

english

File:

PDF, 551 KB

english, 2007

6

Monitoring Tumorigenesis and Senescence In Vivo with a p16INK4a-Luciferase Model

Burd, Christin E., Sorrentino, Jessica A., Clark, Kelly S., Darr, David B., Krishnamurthy, Janakiraman, Deal, Allison M., Bardeesy, Nabeel, Castrillon, Diego H., Beach, David H., Sharpless, Norman E.

Journal:

Year:

2013

Language:

english

File:

PDF, 1.64 MB

english, 2013

7

Senescence in Health and Disease

He, Shenghui, Sharpless, Norman E.

Journal:

Year:

2017

Language:

english

File:

PDF, 1.59 MB

english, 2017

8

Growth and differentiation in hydra. I. The effect of temperature on sexual differentiation in hydra littoralis

Helen D. Park, Norman E. Sharpless, Anne B. Ortmeyer

Journal:

Journal of Experimental Zoology Part A Ecological Genetics and Physiology

Year:

1965

Language:

english

File:

PDF, 560 KB

english, 1965

9

The nuclear magnetic resonance of heterocyclic compounds related to anthracene

Norman E. Sharpless, Robert B. Bradley, James A. Ferretti

Journal:

Magnetic Resonance in Chemistry

Year:

1974

Language:

english

File:

PDF, 608 KB

english, 1974

10

Laboratory studies on N2O relevant to stratospheric processes

Graham Black, Robert M. Hill, Robert L. Sharpless, Tom G. Slanger, Norman Albert

Journal:

Journal of Photochemistry

Year:

1983

Language:

english

File:

PDF, 326 KB

english, 1983

11

Structure-activity studies of aldose reductase inhibitors containing the 4-oxo-4H-chromen ring system

Peter F. Kador, Norman E. Sharpless

Journal:

Biophysical Chemistry

Year:

1978

Language:

english

File:

PDF, 493 KB

english, 1978

12

Alternate g−g−. conformation for dinucleoside phosphates in solution

Che-Hung Lee, Norman E. Sharpless, William H. Jennings

Journal:

Biophysical Chemistry

Year:

1982

Language:

english

File:

PDF, 665 KB

english, 1982

13

Unexpected In Vivo Antagonism between Two Active Agents, Ionizing Radiation and the Farnesyltransferease Inhibitor lonafarnib, in a Genetically Engineered Murine Model of Ras-induced Melanoma

Smith Apisarnthanarax, Kimberly B. Petermann, Adrienne D. Cox, Norman E. Sharpless

Journal:

International Journal of Radiation Oncology*Biology*Physics

Year:

2008

Language:

english

File:

PDF, 43 KB

english, 2008

14

The reaction of dimethyl β-ketoglutarate with 1,2-dicarbonyl compounds. III. Exo-tetracyclo[5.5.1.02,6.010,13]tridecane-4,8,12-trione

Kenner C. Rice, Norman E. Sharpless, Ulrich Weiss, Robert J. Highet

Journal:

Tetrahedron Letters

Year:

1975

Language:

english

File:

PDF, 182 KB

english, 1975

15

Tumor suppressor mechanisms in immune aging

Yan Liu, Norman E Sharpless

Journal:

Current Opinion in Immunology

Year:

2009

Language:

english

File:

PDF, 816 KB

english, 2009

16

Structural Effects on quantitative gas-chromatographic detector response : Methyl esters of dicarboxylic acids

Norman E . Sharpless

Journal:

Journal of Chromatography A

Year:

1963

File:

PDF, 286 KB

1963

17

Expression of p16INK4a in peripheral blood T-cells is a biomarker of human aging

Yan Liu, Hanna K. Sanoff, Hyunsoon Cho, Christin E. Burd, Chad Torrice, Joseph G. Ibrahim, Nancy E. Thomas, Norman E. Sharpless

Journal:

Year:

2009

Language:

english

File:

PDF, 375 KB

english, 2009

18

Hot topics in stem cells and self-renewal: 2010

Norman E. Sharpless

Journal:

Year:

2010

Language:

english

File:

PDF, 70 KB

english, 2010

19

Effects of Some Metabolic Inhibitors on the Pigments of Euglena gracilis in an Acidic Medium

CHARLES L. GREENBLATT, NORMAN E. SHARPLESS

Journal:

Journal of Eukaryotic Microbiology

Year:

1959

Language:

english

File:

PDF, 1.26 MB

english, 1959

20

Phospholipid—Retinaldehyde Complex absorbing at 500 nm

ADAMS, RALPH G., JENNINGS, WILLIAM H., SHARPLESS, NORMAN E.

Journal:

Year:

1970

File:

PDF, 391 KB

1970

21

10.1038/35092592

Sharpless, Norman E., Bardeesy, Nabeel, Lee, Kee-Ho, Carrasco, Daniel, Castrillon, Diego H., Aguirre, Andrew J., Wu, Emily A., Horner, James W., DePinho, Ronald A.

Journal:

Year:

2001

Language:

english

File:

PDF, 243 KB

english, 2001

22

10.1038/35092604

Sharpless, Norman E., Bardeesy, Nabeel, Lee, Kee-Ho, Carrasco, Daniel, Castrillon, Diego H., Aguirre, Andrew J., Wu, Emily A., Horner, James W., DePinho, Ronald A.

Journal:

Year:

2001

Language:

english

File:

PDF, 145 KB

english, 2001

23

10.1038/35092600

Sharpless, Norman E., Bardeesy, Nabeel, Lee, Kee-Ho, Carrasco, Daniel, Castrillon, Diego H., Aguirre, Andrew J., Wu, Emily A., Horner, James W., DePinho, Ronald A.

Journal:

Year:

2001

Language:

english

File:

PDF, 178 KB

english, 2001

24

10.1038/35092609

Sharpless, Norman E., Bardeesy, Nabeel, Lee, Kee-Ho, Carrasco, Daniel, Castrillon, Diego H., Aguirre, Andrew J., Wu, Emily A., Horner, James W., DePinho, Ronald A.

Journal:

Year:

2001

Language:

english

File:

PDF, 159 KB

english, 2001

25

Cancer: Crime and punishment

Sharpless, Norman E., DePinho, Ronald A.

Journal:

Year:

2005

Language:

english

File:

PDF, 183 KB

english, 2005

26

Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation

Bardeesy, Nabeel, Sinha, Manisha, Hezel, Aram F., Signoretti, Sabina, Hathaway, Nathaniel A., Sharpless, Norman E., Loda, Massimo, Carrasco, Daniel R., DePinho, Ronald A.

Journal:

Year:

2002

Language:

english

File:

PDF, 586 KB

english, 2002

27

p16INK4a induces an age-dependent decline in islet regenerative potential

Krishnamurthy, Janakiraman, Ramsey, Matthew R., Ligon, Keith L., Torrice, Chad, Koh, Angela, Bonner-Weir, Susan, Sharpless, Norman E.

Journal:

Year:

2006

Language:

english

File:

PDF, 438 KB

english, 2006

28

Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing

Molofsky, Anna V., Slutsky, Shalom G., Joseph, Nancy M., He, Shenghui, Pardal, Ricardo, Krishnamurthy, Janakiraman, Sharpless, Norman E., Morrison, Sean J.

Journal:

Year:

2006

Language:

english

File:

PDF, 362 KB

english, 2006

29

Cancer biology: Gone but not forgotten

Sharpless, Norman E., DePinho, Ronald A.

Journal:

Year:

2007

Language:

english

File:

PDF, 150 KB

english, 2007

30

ROS as a tumour suppressor?

Ramsey, Matthew R., Sharpless, Norman E.

Journal:

Nature Cell Biology

Year:

2006

Language:

english

File:

PDF, 153 KB

english, 2006

31

Telomeres, p21 and the cancer-aging hypothesis

Bell, Jessica F, Sharpless, Norman E

Journal:

Nature Genetics

Year:

2007

Language:

english

File:

PDF, 205 KB

english, 2007

32

Both products of the mouse Ink4a/Arf locus suppress melanoma formation in vivo

Sharpless, Norman Edward, Kannan, Karuppiah, Xu, Jin, Bosenberg, Marcus Wolfram, Chin, Lynda

Journal:

Year:

2003

Language:

english

File:

PDF, 203 KB

english, 2003

33

The differential impact of p16INK4a or p19ARF deficiency on cell growth and tumorigenesis

Sharpless, Norman E, Ramsey, Matthew R, Balasubramanian, Periasamy, Castrillon, Diego H, DePinho, Ronald A

Journal:

Year:

2004

Language:

english

File:

PDF, 229 KB

english, 2004

34

The genetics of pancreatic adenocarcinoma: a roadmap for a mouse model

Nabeel Bardeesy, Norman E. Sharpless, Ronald A. DePinho, Glenn Merlino

Journal:

Seminars in Cancer Biology

Year:

2001

Language:

english

File:

PDF, 3.06 MB

english, 2001

35

The restricted nature of HIV-1 tropism for cultured neural cells

Norman Sharpless, Don Gilbert, Bernard Vandercam, Jia Min Zhou, Eric Verdin, Gabriele Ronnett, Emily Friedman, Monique Dubois-Dalcq

Journal:

Year:

1992

Language:

english

File:

PDF, 1.11 MB

english, 1992

36

RAS unplugged: Negative feedback and oncogene-induced senescence

Nabeel Bardeesy, Norman E. Sharpless

Journal:

Year:

2006

Language:

english

File:

PDF, 269 KB

english, 2006

37

VHL Inactivation: A New Road to Senescence

William Y. Kim, Norman E. Sharpless

Journal:

Year:

2008

Language:

english

File:

PDF, 210 KB

english, 2008

38

What's So Special about RB?

Christin E. Burd, Norman E. Sharpless

Journal:

Year:

2010

Language:

english

File:

PDF, 151 KB

english, 2010

39

Ink4a/Arf links senescence and aging

Norman E. Sharpless

Journal:

Experimental Gerontology

Year:

2004

Language:

english

File:

PDF, 250 KB

english, 2004

40

INK4a/ARF: A multifunctional tumor suppressor locus

Norman E. Sharpless

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Year:

2005

Language:

english

File:

PDF, 565 KB

english, 2005

41

Epidermal growth factor receptor and Ink4a/Arf: Convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis

Robert M Bachoo, Elizabeth A Maher, Keith L Ligon, Norman E Sharpless, Suzanne S Chan, Mingjian James You, Yi Tang, Jessica DeFrances, Elizabeth Stover, Ralph Weissleder, David H Rowitch, David N Loui

Journal:

Year:

2002

Language:

english

File:

PDF, 809 KB

english, 2002

42

A MOLECULAR MODEL FOR A PHOSPHOLIPID-RETINALDEHYDE COMPLEX ABSORBING AT 500 nm

NORMAN E. SHARPLESS, RALPH G. ADAMS, WILLIAM H. JENNINGS

Journal:

Photochemistry and Photobiology

Year:

1971

Language:

english

File:

PDF, 306 KB

english, 1971

43

Senescence-escape in melanoma

Wenjin Liu, Norman E. Sharpless

Journal:

Pigment Cell & Melanoma Research

Year:

2012

Language:

english

File:

PDF, 52 KB

english, 2012

44

Expression of p16INK4a as a biomarker of T-cell aging in HIV-infected patients prior to and during antiretroviral therapy

Julie A. E. Nelson, Janakiraman Krishnamurthy, Prema Menezes, Yan Liu, Michael G. Hudgens, Norman E. Sharpless, Joseph J. Eron Jr

Journal:

Year:

2012

Language:

english

File:

PDF, 281 KB

english, 2012

45

Physical State Influences on the Intensity of Infrared Absorption Bands

Sharpless, Norman E., Gregory, Dolores A.

Journal:

Applied Spectroscopy

Year:

1963

Language:

english

File:

PDF, 394 KB

english, 1963

46

The Nuclear Magnetic Resonance Spectra of Compounds Related to DDT. I. Non-Aromatic Protons

Sharpless, Norman E., Bradley, Robert B.

Journal:

Applied Spectroscopy

Year:

1965

Language:

english

File:

PDF, 444 KB

english, 1965

47

Nuclear Magnetic Resonance of Compounds Related to DDT: Part II. Aromatic Protons

Sharpless, Norman E., Bradley, Robert B.

Journal:

Applied Spectroscopy

Year:

1968

Language:

english

File:

PDF, 562 KB

english, 1968

48

The Nuclear Magnetic Resonance of DDT and Related Compounds. Part III: Naturally Occurring 13C Spectra

Sharpless, Norman E., Egan, William M., Kennard, Colin H. L.

Journal:

Applied Spectroscopy

Year:

1985

Language:

english

File:

PDF, 275 KB

english, 1985

49

Anomalous Dispersion in the Infrared

SHARPLESS, NORMAN E., GREGORY, DOLORES A.

Journal:

Journal of the Optical Society of America

Year:

1962

Language:

english

File:

PDF, 222 KB

english, 1962

50

The Reactions of Amines and Amino Acids with Maleimides. Structure of the Reaction Products Deduced from Infrared and Nuclear Magnetic Resonance Spectroscopy

Sharpless, Norman E., Flavin, Martin

Journal:

Year:

1966

Language:

english

File:

PDF, 778 KB

english, 1966

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